Loss of DNA repair capacity during successive subcultures of primary rat fibroblasts.
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چکیده
منابع مشابه
Loss of DNA repair capacity during successive subcultures of primary rat fibroblasts
Cultures of fibroblasts from newborn rats and successive subcultures of these cells were treated with 4-nitroquinoline-1-oxide to induce DNA repair. DNA from the cultures was examined by velocity sedimentation in alkaline sucrose gradients immediately after drug treatment and after a post-treatment incubation period of 3 h. Early passage cells were able to repair the damage that appeared as sin...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1977
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.74.2.365